anti-hla antibodies and kidney allograft outcomes in recipients with donor bone marrow cell infusion

نویسندگان

ghasem solgi

department of immunology, school of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran gholamreza pourmand

urology research center, sina hospital, tehran university of medical sciences, tehran, iran abdorasool mehrsai

urology research center, sina hospital, tehran university of medical sciences, tehran, iran mohsen tahei-mahmoudi

urology research center, sina hospital, tehran university of medical sciences, tehran, iran mohammad hossein nicknam

چکیده

background: anti-hla-antibodies are known to affect the allograft survival in transplant recipient patients. objective: the aim of this study was to evaluate the association between anti-hla antibodies and kidney allograft outcomes, particularly in recipients with concur-rent donor bone marrow cell infusion (dbmi). methods: between june 2006 and may 2007, forty living unrelated donor kidney transplants consisting of 20 recipients with dbmi and 20 without infusion entered into the study and were monitored prospectively for one year. pre- and post-transplant (days 14, 30, and 90) sera were screened for the presence of anti-hla class-i and ii antibodies, and subsequently positive sera retested with elisa spe-cific panel for antibody specification. results: of 40 patients, 9 (22.5%) experienced acute rejection episodes (are) (6/20 cases in non-infused versus 3/20 in dbmi patients). the prevalence of anti-hla antibodies before and after transplantation were higher in patients with are compared to non-rejecting ones (88.8% vs. 38.7%, p=0.01 and 66.6% vs. 25.8%, p=0.04, respectively). a total of 10% (4/40) of patients developed donor specific anti-hla antibodies (dsa) and in this regard 2 patients from the control group experienced are. all 3 rejecting patients in dbmi group were negative for dsa and positive for non-dsa. the lower titer of post-transplant anti-hla antibodies were shown in dbmi patients compared to pre-transplantation titer. additionally, the average serum creatinine levels during one year follow up and even in those patients with are were lower compared to controls. con-clusion: our findings reveal an association between pre- and post-transplant anti-hla an-tibodies, and are and also early allograft dysfunction. it suggests that lower incidence of are, undetectable dsa, lower titer of antibodies concomitant with a decrease in serum creatinine level, better allograft function and lower percentages of pra in dbmi patients, could be the probable manifestations of partial hypo-responsiveness against allografts.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Anti-HLA Antibodies and Kidney Allograft Outcomes in Recipients with Donor Bone Marrow Cell Infusion

Background: Anti-HLA-antibodies are known to affect the allograft survival in transplant recipient patients. Objective: The aim of this study was to evaluate the association between anti-HLA antibodies and kidney allograft outcomes, particularly in recipients with concur-rent donor bone marrow cell infusion (DBMI). Methods: Between June 2006 and May 2007, forty living unrelated donor kidney tra...

متن کامل

An attempt to induce tolerance with infusion of donor bone marrow in organ allograft recipients.

Early observations by Snell and Steinmuller provided unequivocal evidence that nonparenchymal cells, resident within the organ play an important role in allograft rejectionl-3. However, despite these findings and the subsequent employment of the term "passenger leukocytes" to illustrate their migratory capacity4, identity of the donor cells involved in allograft rejection (at that time) was nev...

متن کامل

Perioperative donor bone marrow infusion in recipients of organ allografts.

D ESPITE its attended complications. immunosuppression for graft acceptance and the impending threat of chronic rejection are two of the many overwhelming factors that have necessitated the implementation of strategies aimed at inducing donor-specific tolerance (OST). With the postulation that persistence of donor cell chimerism after organ transplantation (Tx) may play a notable role in allogr...

متن کامل

Non-Complement-Binding De Novo Donor-Specific Anti-HLA Antibodies and Kidney Allograft Survival.

C1q-binding ability may indicate the clinical relevance of de novo donor-specific anti-HLA antibodies (DSA). This study investigated the incidence and risk factors for the appearance of C1q-binding de novo DSA and their long-term impact. Using Luminex Single Antigen Flow Bead assays, 346 pretransplant nonsensitized kidney recipients were screened at 2 and 5 years after transplantation for de no...

متن کامل

Complement-binding anti-HLA antibodies and kidney-allograft survival.

BACKGROUND Anti-HLA antibodies hamper successful transplantation, and activation of the complement cascade is involved in antibody-mediated rejection. We investigated whether the complement-binding capacity of anti-HLA antibodies plays a role in kidney-allograft failure. METHODS We enrolled patients who received kidney allografts at two transplantation centers in Paris between January 1, 2005...

متن کامل

Enhancement of donor cell chimerism in whole organ allograft recipients by adjuvant bone marrow transplantation.

THE ADVENT of novel immunosuppressive agents has made successful transplantation of organ allografts a clinical reality. However, chronic use of these nonspecific drugs is associated with unwanted side effects; necessitating the evolution of strategies that would allow for the induction of donor-specific tolerance, enhancing allograft survival and ultimately leading to reduction or withdrawal o...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of immunology

جلد ۷، شماره ۱، صفحات ۱۸-۲۹

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023